Pregnancy rates for in vitro fertilization procedures with assisted hatching have been shown in some published studies to be higher than for IVF without hatching. There is an improvement in the rate of embryo implantation and pregnancy with the use of assisted hatching.
During the cleavage of the early foetus, zona pellucida hardens. This development is normal and the purpose is to keep the cells in the egg together. Removing the egg for in vitro fertilization and micro insemination takes it out of its natural environment. This procedure tends to lead to egg shells that harden faster those of normally fertilized eggs.
Especially women older than 37 years of age, have a tendency to produce eggs with a harder zona pellucida than younger women. The same goes for women with a high level of follicle stimulating hormone (FSH). This can be diagnosed from a blood sample.
The problem of a harder zona pellucida is that the egg may not hatch and thus not attach to the woman's womb. Hatching of the egg is necessary to become pregnant. We know that eggs from older women have problems hatching, explaining why some older women have problems becoming pregnant.
Laser assisted hatching is one out of several methods to help the fertilized egg hatch and attach to the womb. Other methods are acid or mechanical hatching of one a part of zona pellucida. At Nordica we offer laser assisted hatching, which is a gentle and safe way to weaken a part of zona pellucida. After treating the fertilized egg with laser assisted hatching, we transfer the embryo into the woman's womb. In most cases the embryo will attach for normal growth and development.
Scientific experiments have shown that one method of assisted hatching is not superior to another. Nor are eggs damaged by assisted hatching.
Recent meta-research (comparison of different relevant researches) showed that women who have undergone repeated IVF treatments without results, double their chances of a pregnancy by use of assisted laser hatching.